The lyrics describe a man experiencing a strange and unfamiliar feeling, unsure of which direction to take when his left eye starts jumping. He suspects that his significant other may be involved with someone else, leading to a sense of unease and discomfort.

Meaning of "When My Left Eye Jumps" by Buddy Guy

The lyrics of "When My Left Eye Jumps" by Buddy Guy describe a sense of suspicion and unease in a romantic relationship. The protagonist is feeling a strange sensation, symbolized by his left eye jumping, which he has never experienced before. This feeling is tied to his intuition about his partner's possible infidelity. He senses that something is wrong and that his partner may be involved with another person, leading to a sense of confusion and betrayal. The reference to a black cat bone implies that the partner may be using supernatural means to control or influence the protagonist. Overall, the song captures the emotional turmoil and uncertainty that can come with suspecting betrayal and questioning the trust in a relationship.