The narrator and his uncle go on a journey from Colorado to West Texas, making a stop in Santa Fe. While in West Texas, they encounter cowboys in town for a round-up and end up in a friendly card game that escalates into violence, resulting in the uncle being left behind as the narrator takes off with the gold.

Meaning of "Me And My Uncle" by John Denver

The lyrics of "Me And My Uncle" tell the story of a reckless journey that ends in betrayal. The uncle, portrayed as a questionable yet influential figure, teaches the narrator lessons that ultimately lead to the uncle's demise. The song explores the themes of loyalty, honesty, and greed, as well as the harsh reality of life in the Wild West where violence and deceit were common. The departure of the narrator with the gold, leaving his uncle behind, symbolizes the ruthless nature of human behavior when faced with the opportunity for personal gain.